We measure nocturnal scratching as it happens, and cool the skin in response.
Histo-Cooling is a single sealed device. It watches for scratching during sleep, cools the skin when scratching starts, and keeps a clinical-grade record of every episode. We built it for research into atopic dermatitis, chronic urticaria, and similar conditions where night-time itch carries the burden.
The most important endpoint nobody can measure
Nocturnal itch is the core burden marker in dermatology, yet it is still scored from next-morning recall.
UAS7 / SCORAD / NRS all rely on morning recall, which systematically underestimates night events.
Multiple episodes in one night blur together, with no timing, duration, or distribution.
Actigraphy captures scratching only indirectly, and only records it. Nothing acts on it.
Diary compliance collapses after week four, leaving gaps in the longitudinal data.
One sealed device closes the whole loop
Detect, respond, record, and adapt, all inside one fan-less, pump-less, disinfectant-wipeable IP68 device.
Detect scratch
IMU, sleep state machine, and frequency-domain analysis identify valid scratch episodes.
Active cooling
Cools the surface to break the itch-scratch cycle, bounded by a hard-coded safety envelope.
Signed data
Cryptographically signed time-series mapped to SCORAD / UAS7 / NRS endpoints.
Efficacy feedback
Adjusts intensity by whether the response worked, clamped to the safety envelope.
Three interlocking layers
Closed-loop method
Sleep state machine, frequency-domain scratch detection, a closed-loop response sequence, and event-to-endpoint mapping.
Hermetic cooling
Thermoelectric cooling, a liquid-metal thermal bus, and a PCM buffer; no fan, no pump; IP68, disinfectable.
Trustworthy data
Hard-coded safety envelope, sham mode for double-blinding, device signing, offline export, and fault-tolerant storage.
From patients to the world
Sleep & quality of life
Objectively quantify nocturnal scratching, and cool the skin as it flares.
Objective endpoint
An objective endpoint for biologics R&D, and import substitution for trial instruments.
Sovereignty & voice
A locally controlled high-end device that raises Chinese research credibility.
Global health
An objective, reproducible nocturnal endpoint for global itch research, offered as an open standard.
From patents to clearance
Phase 0
6+ layered filings in place; spec frozen.
Phase 1
Prototype; bench validation; security hardening; NMPA pre-submission.
Phase 2
Single-center pilot; reference-cohort calibration; pharma/CRO LOIs.
Phase 3
NMPA Class II; FDA De Novo prep; initial trial deployment.
Let us turn it from filings into a prototype
We are raising seed funding and seeking R&D, clinical, and pharma partnerships. Incubators, investors, dermatology research centers, and biologics sponsors welcome.
Explore the technology